| 2023-08-17 19:00:00August 17, 2023 | Athens  | 13 - 28 |  Philo | N/A | Recap |
| 2023-08-17 19:00:00August 17, 2023 | Waterford  | 20 - 0 |  Alexander | N/A | Recap |
| 2023-08-17 19:00:00August 17, 2023 | Portsmouth  | 59 - 29 |  Valley | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Chillicothe  | 18 - 21 | St.Charles | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | New Lexington  | 28 - 14 |  Fairfield Union | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Jackson  | 22 - 0 |  Logan | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Circleville  | 0 - 28 |  John Glenn | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Hillsboro  | 27 - 38 | Western Brown | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Marietta  | 18 - 21 |  Fort Frye | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Waverly  | 26 - 27 |  Miami Trace | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Logan Elm  | 39 - 23 |  Zane Trace | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Sheridan  | 33 - 14 | Licking Valley | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Vinton County  | 20 - 21 |  Unioto | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Warren  | 60 - 0 |  Belpre | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | McClain  | 41 - 23 |  Adena | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Washington  | 14 - 62 |  London | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Symmes Valley  | 7 - 39 |  Chesapeake | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Portsmouth West  | 29 - 32 |  Fairland | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Ironton  | 17 - 14 |  Wheelersburg | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Minford  | 17 - 7 |  Rock Hill | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Southeastern  | 8 - 38 |  Northwest | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Goshen | 22 - 28 |  Piketon | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Eastern Meigs  | 55 - 6 |  River Valley | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | South Point  | 7 - 46 | Boyd County (KY) | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Wellston  | 12 - 9 |  Oak Hill | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Madison-Plains | 12 - 38 |  Westfall | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Crooksville  | 59 - 7 |  Fisher Catholic | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Coal Grove  | 36 - 28 | Greenup County (KY) | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Trimble  | 14 - 12 |  Nelsonville-York | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Huntington  | 0 - 12 |  East Clinton | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Paint Valley  | 35 - 14 | Blanchester | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Miller  | 15 - 43 |  Beaver Eastern | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Rosecrans  | 30 - 42 |  Sciotoville | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Manchester  | 6 - 78 |  Notre Dame | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Southern  | 28 - 32 |  South Gallia | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Lancaster  | 24 - 17 |  Teays Valley | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Harvest Prep | 38 - 16 |  Bloom-Carroll | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Hamilton Township  | 41 - 19 | Whitehall-Yearling | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Cols.DeSales | 21 - 17 |  Tri-Valley | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Zanesville  | 21 - 35 | Newark | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Meadowbrook  | 20 - 17 |  Maysville | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | River View  | 0 - 52 |  Morgan | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Ridgewood | 22 - 21 |  Coshocton | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Amanda-Clearcreek  | 38 - 6 | Cols. Linden McKinley | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Liberty Union  | 0 - 48 | Heath | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Danville | 55 - 21 |  Worthington Christian | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | West Muskingum  | 48 - 28 | Lakewood | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Miami Valley Chr Acad | 6 - 42 |  Grove City Christian | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Newcomerstown | 42 - 7 |  Berne Union | N/A | Recap |
| 2023-08-18 19:00:00August 18, 2023 | Millersport  | 14 - 41 |  Beallsville | N/A | Recap |
| 2023-08-19 16:08:01August 19, 2023 | Fairfield Christian Academy  | 42 - 0 |  Green | N/A | Recap |
| 2023-08-19 19:00:00August 19, 2023 | Gallia Academy  | 39 - 0 |  Meigs | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Teays Valley | 28 - 6 | Logan | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Athens | 0 - 30 | Gallia Academy | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | London | 21 - 0 | Chillicothe | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Circleville | 8 - 19 | Vinton County | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Hillsboro | 56 - 14 | Goshen | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | West Muskingum | 38 - 20 | Marietta | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Miami Trace | 21 - 24 |  Wilmington | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Meigs | 0 - 38 | Fairfield Union | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Westfall | 6 - 43 | Logan Elm | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Watkins Memorial | 19 - 24 | Sheridan | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Morgan | 33 - 22 | Warren | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Northwest | 13 - 14 | McClain | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Unioto | 29 - 10 | Amanda-Clearcreek | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Western Brown | 20 - 39 | Washington | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Zane Trace | 28 - 42 | Waverly | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Chesapeake | 22 - 21 | Minford | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Fairland | 56 - 21 | Wellston | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Maysville | 10 - 33 | New Lexington | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Piketon | 34 - 0 | Oak Hill | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Portsmouth West | 31 - 14 | Portsmouth | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | River Valley | 13 - 34 | South Gallia | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Wheelersburg | 20 - 17 | Cin.McNicholas | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Belpre | 0 - 62 | Fort Frye | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Crooksville | 31 - 6 | Southern | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Nelsonville-York | 21 - 9 | Newark Catholic | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Rock Hill | 28 - 0 | Symmes Valley | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Fairfield Christian Academy | 45 - 43 | Adena | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Beaver Eastern | 31 - 14 | Huntington | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | West Jefferson | 49 - 13 | Paint Valley | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Madison-Plains | 6 - 27 | Southeastern | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Sciotoville | 46 - 16 | Manchester | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Eastern Meigs | 40 - 7 | Rosecrans | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Grove City Christian | 49 - 13 | Green | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Frontier | 12 - 44 | Miller | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Notre Dame | 28 - 12 | Berne Union | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Caldwell  | 41 - 14 | Waterford | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Bloom-Carroll | 28 - 17 | Cols. Hartley | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Hamilton Township | 57 - 36 | Lancaster | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | John Glenn | 42 - 14 |  Cambridge | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Tri-Valley | 42 - 7 | Licking Heights | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Zanesville | 0 - 22 | Louisville | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Philo | 20 - 14 | Carrollton | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | River View | 6 - 57 | Ridgewood | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Coshocton | 36 - 50 | Johnstown-Monroe | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Lakewood | 28 - 23 | Liberty Union | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Worthington Christian | 48 - 6 | Dayton Christian | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Indian Valley | 47 - 16 | Meadowbrook | N/A | Recap |
| 2023-08-25 19:00:00August 25, 2023 | Vanlue | 56 - 28 | Millersport | N/A | Recap |
| 2023-08-26 13:00:00August 26, 2023 | Valley | 6 - 52 | Coal Grove | N/A | Recap |
| 2023-08-26 19:00:00August 26, 2023 | Tuscarawas Cent Cath | 6 - 35 | Fisher Catholic | N/A | Recap |
| 2023-08-26 19:00:00August 26, 2023 | Ironton | 35 - 14 | Jackson | N/A | Recap |
| 2023-08-26 19:00:00August 26, 2023 | Alexander | 14 - 27 | South Point | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Logan | 10 - 41 | Sheridan | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Marietta | 28 - 19 | Athens | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Westerville North | 42 - 0 | Chillicothe | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Portsmouth West | 49 - 34 | Hillsboro | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Miami Trace | 20 - 41 | Logan Elm | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Fairfield Union | 42 - 3 | Warren | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Marion-Franklin | 6 - 42 | Washington | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Belpre | 0 - 44 | Alexander | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Southern | 13 - 47 | Chesapeake | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Ironton | 62 - 14 | Fairland | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Meigs | 42 - 48 | Coal Grove | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Minford | 42 - 18 | Wellston | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Portsmouth | 22 - 28 | Greenup County (KY) | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Symmes Valley | 30 - 8 | River Valley | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | South Point | 28 - 7 | Russell (KY) | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Zane Trace | 17 - 14 | North Union | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Oak Hill | 13 - 47 | Rock Hill | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Southeastern | 20 - 36 | Beaver Eastern | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Green | 13 - 10 | Manchester | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Waterford | 24 - 22 | Shenandoah | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Cols. Centennial | 0 - 49 | Hamilton Township | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Clinton-Massie  | 24 - 14 | Tri-Valley | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | St.Clairsville | 48 - 7 | Zanesville | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Worthington Christian | 20 - 7 | Centerburg | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Garaway | 28 - 0 | West Muskingum | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Fort Frye | 22 - 15 | Bellaire | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Westfall | 48 - 36 | Circleville | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Jackson | 28 - 20 | Wheelersburg | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Point Pleasant (WV) | 12 - 42 | Gallia Academy | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Trimble | 6 - 20 | Vinton County | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Paint Valley | 29 - 15 | McClain | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Unioto | 14 - 28 | Waverly | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | John Glenn | 14 - 13 | New Lexington | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Northwest | 44 - 26 | Huntington | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Valley | 14 - 42 | Piketon | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Berne Union | 14 - 47 | Crooksville | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Liberty Union | 19 - 47 | Nelsonville-York | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Adena | 14 - 48 | Amanda-Clearcreek | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Miller | 27 - 20 | Sciotoville | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | South Gallia | 8 - 34 | Eastern Meigs | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Watkins Memorial | 26 - 7 | Teays Valley | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Jonathon Alder | 0 - 42 | Bloom-Carroll | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Maysville | 48 - 13 | Coshocton | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Morgan | 12 - 34 | Philo | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Massillon Tuslaw | 40 - 6 | River View | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Meadowbrook | 60 - 35 | Cambridge | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Grove City Christian | 0 - 22 | Mount Gilead | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Danville | 41 - 7 | Fairfield Christian Academy | N/A | Recap |
| 2023-09-01 19:00:00September 1, 2023 | Millersport | 0 - 55 | Cols. West | N/A | Recap |
| 2023-09-02 19:00:00September 2, 2023 | Steubenville Cath. Cent | 28 - 14 | Rosecrans | N/A | Recap |
| 2023-09-02 19:00:00September 2, 2023 | Fisher Catholic | 17 - 46 | Notre Dame | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Warren | 12 - 20 | Logan | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Athens | 55 - 7 | Alexander | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Chillicothe | 7 - 40 | Harvest Prep | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Williamsburg | 57 - 27 | Hillsboro | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Western Brown | 48 - 56 | Jackson | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Bethel-Tate | 20 - 34 | Miami Trace | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Hamilton Township | 38 - 14 | Fairfield Union | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Gallia Academy | 47 - 21 | Chesapeake | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Sheridan | 29 - 13 | Morgan | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Meigs | 0 - 54 | Vinton County | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | McClain | 22 - 6 | East Clinton | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Unioto | 42 - 26 | Westfall | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Washington | 48 - 18 | Buckeye Valley | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Fairland | 61 - 27 | Trimble | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Ironton | 21 - 35 | Cabell Midland (WV) | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Huntington | 7 - 41 | Piketon | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Rock Hill | 27 - 28 | Portsmouth | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Coal Grove | 20 - 33 | South Point | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Wellston | 10 - 49 | Portsmouth West | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Paint Valley | 49 - 9 | Southeastern | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Beaver Eastern | 39 - 13 |  Fayetteville | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Notre Dame | 26 - 42 | Eastern Meigs | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Southern | 49 - 0 | Green | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | South Gallia | 39 - 6 | Manchester | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Millersport | 16 - 48 | Miller | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Tug Valley(WV) | 51 - 8 | Symmes Valley | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Amanda-Clearcreek | 7 - 41 | Bloom-Carroll | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Tri-Valley | 38 - 13 | Maysville | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Zanesville | 22 - 16 | Lakewood | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Worthington Christian | 25 - 49 | Cin. Hills Christian | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Fort Frye | 42 - 24 | Bishop Tonnos (ON) | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Grove City Christian | 14 - 17 | Fairfield Christian Academy | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Logan Elm | 40 - 19 | Circleville | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Claymont | 28 - 32 | Marietta | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Waverly | 48 - 8 | Valley | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | New Lexington | 13 - 34 | West Muskingum | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Wheelersburg | 56 - 0 | Northwest | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Nelsonville-York | 54 - 0 | River Valley | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Zane Trace | 49 - 39 | Adena | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Belpre | 6 - 47 | Waterford | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Crooksville | 21 - 24 | Meadowbrook | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Teays Valley | 31 - 19 | Liberty Union | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Coshocton | 7 - 30 | John Glenn | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Philo | 46 - 6 | River View | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Berne Union | 21 - 23 | Rosecrans | N/A | Recap |
| 2023-09-08 19:00:00September 8, 2023 | Martins Ferry  | 48 - 20 | Fisher Catholic | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Chillicothe | 17 - 14 | Logan | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Vinton County | 35 - 13 | Athens | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Circleville | 14 - 3 | Amanda-Clearcreek | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | East Clinton | 12 - 32 | Hillsboro | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Jackson | 44 - 14 | Hamilton Ross | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Marietta | 43 - 3 | Ripley (WV) | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Western Brown | 31 - 63 | Miami Trace | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Fairfield Union | 21 - 48 | Logan Elm | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Gallia Academy | 50 - 18 | Portsmouth | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Sheridan | 14 - 0 | John Glenn | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Fort Frye | 16 - 7 | Warren | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Cin. Hills Christian | 25 - 27 | McClain | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Huntington | 0 - 51 | Unioto | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Washington | 21 - 48 | Monroe | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Waverly | 21 - 24 | Portsmouth West | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Alexander | 0 - 27 | Wellston | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Coal Grove | 44 - 30 | Chesapeake | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Fairland | 40 - 7 | Rock Hill | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | South Point | 8 - 42 | Ironton | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | River Valley | 6 - 40 | Meigs | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Northwest | 21 - 63 | Minford | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Tri-Valley | 34 - 8 | New Lexington | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Piketon | 24 - 35 | Zane Trace | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Valley | 0 - 35 | Wheelersburg | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Paint Valley | 41 - 20 | Westfall | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Belpre | 0 - 49 | Caldwell | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Crooksville | 0 - 20 | Maysville | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Nelsonville-York | 26 - 13 | Cols. Bexley | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Oak Hill | 6 - 32 | South Gallia | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Cin.Woodward | 0 - 15 | Trimble | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Adena | 44 - 31 | Southeastern | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Beaver Eastern | 50 - 49 | Southern | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Sciotoville | 36 - 40 | Bradford | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Eastern Meigs | 21 - 20 | Waterford | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Green | 12 - 36 | Fairview (KY) | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Manchester | 12 - 46 | Symmes Valley | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Berne Union | 20 - 16 | Miller | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Notre Dame | 0 - 36 | Williamsburg | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Teays Valley | 17 - 51 | Hamilton Township | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Bloom-Carroll | 35 - 15 | Liberty Union | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Heath | 40 - 20 | Zanesville | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Coshocton | 34 - 35 | Morgan | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | West Muskingum | 21 - 0 | Philo | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Meadowbrook | 63 - 0 | River View | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Arlington | 28 - 21 | Worthington Christian | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Fairfield Christian Academy | 50 - 21 | Fisher Catholic | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Millersport | 20 - 43 |  Hundred (WV) | N/A | Recap |
| 2023-09-15 19:00:00September 15, 2023 | Rosecrans | 35 - 27 | Grove City Christian | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Logan | 21 - 30 | Athens | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Chillicothe | 17 - 23 | Hillsboro | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Washington | 21 - 49 | Jackson | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | McClain | 20 - 29 | Miami Trace | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Bloom-Carroll | 45 - 3 | Fairfield Union | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Fairland | 40 - 35 | Gallia Academy | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | River View | 0 - 62 | Sheridan | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Alexander | 0 - 62 | Vinton County | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Warren | 18 - 17 | Point Pleasant (WV) | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Unioto | 45 - 22 | Piketon | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Circleville | 7 - 45 | Teays Valley | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Williamstown (WV) | 22 - 19 | Marietta | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Liberty Union | 7 - 35 | Logan Elm | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Warren | 18 - 17 | Point Pleasant (WV) | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Oak Hill | 7 - 56 | Waverly | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Chesapeake | 7 - 48 | Ironton | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Meigs | 14 - 47 | Nelsonville-York | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Portsmouth West | 34 - 7 | Minford | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | New Lexington | 19 - 7 | Coshocton | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Northwest | 6 - 7 | Valley | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Portsmouth | 14 - 6 | Coal Grove | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Wellston | 48 - 12 | River Valley | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Rock Hill | 20 - 53 | South Point | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Wheelersburg | 16 - 32 | Harvest Prep | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Westfall | 62 - 28 | Southeastern | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Huntington | 12 - 35 | Zane Trace | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Paden City (WV) | 49 - 7 | Belpre | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Philo | 32 - 0 | Crooksville | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Trimble | 59 - 19 | Southern | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Adena | 21 - 76 | Paint Valley | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Sciotoville | 20 - 43 | Beaver Eastern | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Eastern Meigs | 22 - 28 | Tucker County (WV) | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Symmes Valley | 38 - 21 | Green | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Miller | 27 - 37 | Grove City Christian | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Frontier | 0 - 31 | Waterford | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Amanda-Clearcreek | 14 - 47 | Hamilton Township | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | John Glenn | 45 - 6 | Meadowbrook | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Morgan | 28 - 56 | Tri-Valley | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Licking Valley | 42 - 0 | Zanesville | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Maysville | 0 - 42 | West Muskingum | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Pandora-Gilboa | 48 - 14 | Worthington Christian | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Fairfield Christian Academy | 7 - 36 | Martins Ferry | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Fisher Catholic | 27 - 48 | Rosecrans | N/A | Recap |
| 2023-09-22 19:00:00September 22, 2023 | Millersport | 0 - 38 | Berne Union | N/A | Recap |
| 2023-09-23 19:00:00September 23, 2023 | Fort Frye | 0 - 41 | Linsly (WV) | N/A | Recap |
| 2023-09-23 19:00:00September 23, 2023 | Notre Dame | 40 - 6 | South Gallia | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Logan | 17 - 0 | Marietta | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Athens | 48 - 27 | Meigs | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Chillicothe | 17 - 20 | McClain | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Hamilton Township | 55 - 19 | Circleville | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Hillsboro | 36 - 6 | Washington | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Miami Trace | 13 - 42 | Jackson | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Fairfield Union | 17 - 7 | Liberty Union | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Gallia Academy | 28 - 12 | Coal Grove | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Logan Elm | 6 - 35 | Bloom-Carroll | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Philo | 0 - 33 | Sheridan | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Vinton County | 33 - 0 | Northwest | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Warren | 20 - 31 | John Marshall (WV) | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Adena | 0 - 52 | Unioto | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Waverly | 33 - 7 | Minford | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | River Valley | 0 - 21 | Alexander | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Portsmouth | 28 - 6 | Chesapeake | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | South Point | 14 - 35 | Fairland | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Ironton | 42 - 0 | Rock Hill | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | New Lexington | 28 - 35 | Morgan | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Piketon | 30 - 49 | Paint Valley | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Nelsonville-York | 46 - 12 | Wellston | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Valley | 7 - 41 | Portsmouth West | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Zane Trace | 42 - 14 | Westfall | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Belpre | 0 - 40 | Trimble | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | West Muskingum | 48 - 0 | Crooksville | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Southeastern | 12 - 47 | Huntington | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Beaver Eastern | 40 - 0 | Symmes Valley | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | South Gallia | 46 - 8 | Sciotoville | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Buffalo (WV) | 16 - 59 | Eastern Meigs | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Green | 0 - 72 | Notre Dame | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Fayetteville | 22 - 12 | Manchester | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Miller | 43 - 20 | Fisher Catholic | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Southern | 7 - 49 | Waterford | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Teays Valley | 34 - 21 | Amanda-Clearcreek | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Maysville | 7 - 10 | John Glenn | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | River View | 0 - 59 | Tri-Valley | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Zanesville | 7 - 35 | Licking Heights | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Coshocton | 55 - 22 | Meadowbrook | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Grandview Heights | 14 - 21 | Worthington Christian | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Fort Frye | 13 - 20 | Point Pleasant (WV) | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Berne Union | 0 - 42 | Martins Ferry | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Rosecrans | 58 - 61 | Fairfield Christian Academy | N/A | Recap |
| 2023-09-29 19:00:00September 29, 2023 | Grove City Christian | 55 - 0 | Millersport | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Morgan | 13 - 42 | West Muskingum | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Logan | 21 - 23 | Minford | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Wellston | 27 - 48 | Athens | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Miami Trace | 47 - 7 | Chillicothe | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Fairfield Union | 42 - 0 | Circleville | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Hillsboro | 21 - 63 | Jackson | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Marietta | 48 - 15 | Meigs | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Rock Hill | 7 - 44 | Gallia Academy | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Logan Elm | 35 - 14 | Amanda-Clearcreek | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Sheridan | 48 - 0 | Maysville | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Vinton County | 69 - 12 | River Valley | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Warren | 49 - 21 | Cambridge | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | McClain | 25 - 49 | Washington | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Unioto | 27 - 14 | Zane Trace | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Wheelersburg | 40 - 7 | Waverly | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Alexander | 0 - 33 | Nelsonville-York | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Chesapeake | 20 - 38 | South Point | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Fairland | 43 - 27 | Portsmouth | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Coal Grove | 12 - 54 | Ironton | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Meadowbrook | 12 - 42 | New Lexington | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Northwest | 6 - 48 | Portsmouth West | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Piketon | 46 - 26 | Southeastern | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Westfall | 56 - 10 | Adena | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Southern | 41 - 0 | Belpre | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Crooksville | 14 - 41 | Coshocton | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Valley | 40 - 13 | Oak Hill | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Trimble | 20 - 21 | Eastern Meigs | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Paint Valley | 41 - 0 | Huntington | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Notre Dame | 25 - 31 | Beaver Eastern | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Symmes Valley | 12 - 34 | Sciotoville | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Green | 19 - 36 | South Gallia | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Fairfield Christian Academy | 28 - 21 | Miller | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Waterford | 14 - 28 | Harrison Central | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Bloom-Carroll | 42 - 7 | Teays Valley | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Liberty Union | 14 - 35 | Hamilton Township | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | John Glenn | 63 - 0 | River View | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Tri-Valley | 52 - 35 | Philo | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Granville | 41 - 0 | Zanesville | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Cols. Academy | 42 - 6 | Worthington Christian | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Fort Frye | 35 - 6 | Caldwell | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Berne Union | 6 - 38 | Grove City Christian | N/A | Recap |
| 2023-10-06 19:00:00October 6, 2023 | Rosecrans | 6 - 42 | Grandview Heights | N/A | Recap |
| 2023-10-07 19:00:00October 7, 2023 | Fisher Catholic | - | Millersport | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Fort Frye | 26 - 14 | Logan | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | River Valley | 8 - 54 | Athens | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Washington | 13 - 0 | Chillicothe | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Circleville | 7 - 21 | Liberty Union | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Hillsboro | 14 - 13 | Miami Trace | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Jackson | 62 - 14 | McClain | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Point Pleasant (WV) | 47 - 41 | Marietta | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Amanda-Clearcreek | 14 - 35 | Fairfield Union | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Gallia Academy | 17 - 27 | Ironton | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Teays Valley | 28 - 35 | Logan Elm | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Sheridan | 17 - 28 | Tri-Valley | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Nelsonville-York | 7 - 13 | Vinton County | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Alexander | 7 - 48 | Warren | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Unioto | 45 - 7 | Paint Valley | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Waverly | 67 - 23 | Northwest | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Chesapeake | 21 - 33 | Rock Hill | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Coal Grove | 22 - 56 | Fairland | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Wellston | 27 - 18 | Meigs | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Minford | 0 - 61 | Wheelersburg | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Crooksville | 0 - 35 | New Lexington | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Piketon | 44 - 41 | Adena | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Portsmouth | 21 - 7 | South Point | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Portsmouth West | 49 - 14 | Oak Hill | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Huntington | 14 - 41 | Westfall | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Southeastern | 16 - 49 | Zane Trace | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Eastern Meigs | 49 - 6 | Belpre | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Waterford | 14 - 8 | Trimble | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Grandview Hts. | 35 - 34 | Valley | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Beaver Eastern | 27 - 8 | South Gallia | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Sciotoville | 39 - 0 | Green | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Manchester | 14 - 58 | Southern | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Miller | 62 - 34 | Rosecrans | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Symmes Valley | 12 - 48 | Notre Dame | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Hamilton Township | 31 - 28 | Bloom-Carroll | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | John Glenn | 37 - 12 | Philo | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Zanesville | 0 - 34 | Watkins Memorial | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Maysville | 56 - 0 | River View | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Meadowbrook | 26 - 69 | Morgan | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Coshocton | 56 - 57 | West Muskingum | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Worthington Christian | 22 - 21 | Grove City Christian | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Fisher Catholic | 8 - 6 | Berne Union | N/A | Recap |
| 2023-10-13 19:00:00October 13, 2023 | Fairfield Christian Academy | 56 - 8 | Millersport | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Logan | 33 - 0 | Zanesville | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Athens | 19 - 13 | Nelsonville-York | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Jackson | 48 - 7 | Chillicothe | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Bloom-Carroll | 40 - 0 | Circleville | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | McClain | 21 - 13 | Hillsboro | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Marietta | 28 - 24 | Warren | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Miami Trace | 21 - 14 | Washington | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Fairfield Union | 21 - 14 | Teays Valley | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | South Point | 0 - 28 | Gallia Academy | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Logan Elm | 28 - 0 | Hamilton Township | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | New Lexington | 22 - 33 | Sheridan | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Vinton County | 49 - 0 | Wellston | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Southeastern | 8 - 56 | Unioto | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Cin. Mt. Healthy | 6 - 42 | Waverly | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Meigs | 46 - 6 | Alexander | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Chesapeake | 2 - 38 | Fairland | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Ironton | 21 - 6 | Portsmouth | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Minford | 0 - 24 | Valley | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Oak Hill | 37 - 40 | Northwest | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Westfall | 56 - 39 | Piketon | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | River Valley | 0 - 46 | Trimble | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Wheelersburg | 35 - 7 | Portsmouth West | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Zane Trace | 34 - 31 | Paint Valley | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Clay-Battelle (WV) | 13 - 31 | Belpre | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Morgan | 33 - 7 | Crooksville | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Rock Hill | 23 - 16 | Coal Grove | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Adena | 35 - 14 | Huntington | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Green | 7 - 43 | Beaver Eastern | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Sciotoville | 42 - 50 | Notre Dame | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Manchester | 6 - 47 | Miller | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | South Gallia | 32 - 6 | Symmes Valley | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Waterford | 0 - 16 | Fort Frye | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Tri-Valley | 42 - 7 | John Glenn | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Philo | 7 - 24 | Maysville | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | River View | 6 - 44 | Coshocton | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Liberty Union | 6 - 11 | Amanda-Clearcreek | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Cols. Bexley | 41 - 0 | Worthington Christian | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | West Muskingum | 49 - 10 | Meadowbrook | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Grove City Christian | 35 - 3 | Fisher Catholic | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Fairfield Christian Academy | 35 - 0 | Berne Union | N/A | Recap |
| 2023-10-20 19:00:00October 20, 2023 | Rosecrans | 40 - 8 | Millersport | N/A | Recap |
| 2023-10-21 19:00:00October 21, 2023 | Southern | 13 - 48 | Eastern Meigs | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Eastern Meigs | 48 - 0 | Berne Union | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Beaver Eastern | 41 - 27 |  Shadyside | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Caldwell | 41 - 14 | Bridgeport | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Fairfield Christian Academy | 61 - 54 | Sciotoville | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | River | 49 - 21 | Rosecrans | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Notre Dame | 65 - 16 | Beallsville | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Waterford | 35 - 12 | Miller | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Monroe Central  | 31 - 21 | South Gallia | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Fort Frye | 35 - 21 | Tuscarawas Valley | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Garaway | 45 - 7 | Rock Hill | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | West Jefferson | 45 - 14 | Grove City Christian | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Northmor | 44 - 22 | Coal Grove | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Elgin | 6 - 37 | Trimble | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Nelsonville-York | 20 - 12 | Bellaire | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Paint Valley | 37 - 23 | Parkway | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | West Liberty | 47 - 7 | Valley | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Zane Trace | 24 - 14 | Madison | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Valley View | - | Westfall | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Ironton | 56 - 6 | Worthington Christian | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Fairland | 38 - 50 | Portsmouth | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Barnesville | 56 - 20 | South Point | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Harvest Prep | 55 - 8 | New Lexington | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | West Muskingum | 42 - 26 |  Union Local | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Columbus Academy | - | Utica | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Wheelersburg | 34 - 0 | Columbus Africentric | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Portsmouth West | 15 - 27 | Heath | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Sheridan | 49 - 28 | Morgan | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Logan Elm | 27 - 48 | Indian Valley | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Gallia Academy | 34 - 6 | Vinton County | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Biship Hartley | 1 - 0 | Philo | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Unioto | 21 - 56 | Urbana | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Shawnee | 37 - 7 | Waverly | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Wyoming | 42 - 0 | Washington | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Cincinnati Taft | 39 - 7 | McClain | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Celina | 49 - 7 | Hillsboro | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Jackson | 49 - 14 | Marietta | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Bloom-Carroll | 58 - 14 | Athens | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Tri-Valley | 49 - 12 | Buckeye Valley | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Hamilton Township | 34 - 55 | Miami Trace | N/A | Recap |
| 2023-10-27 19:00:00October 27, 2023 | Bellefontaine | 49 - 7 | John Glenn | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Eastern Meigs | 55 - 14 | Monroe Central | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Beaver Eastern | 21 - 26 | Waterford | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Caldwell | 50 - 0 | Notre Dame | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Fairfield Christian Academy | 15 - 48 | River | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Fort Frye | 50 - 13 | Newcomerstown | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | West Jefferson | 29 - 7 | Nelsonville-York | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Northmor | 31 - 6 | Trimble | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Cincinnati Country Day | 26 - 14 | Paint Valley | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Zane Trace | 28 - 30 | Purcell Marian | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Ironton | 37 - 28 | Heath | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Barnesville | 19 - 17 | Columbus Academy | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Harvest Prep | 24 - 0 | West Muskingum | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Wheelersburg | 34 - 0 | Portsmouth | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Sheridan | 42 - 0 | Gallia Academy | N/A | Recap |
| 2023-11-03 19:00:00November 3, 2023 | Jackson |
