| Valley vs Portsmouth | 2019-08-29 19:00:00August 29, 2019 |   Valley vs Portsmouth | 19:00:007:00 pm | N/A |
| Dover vs Mississauga Lorne Park (ON) | 2019-08-29 19:00:00August 29, 2019 |  Dover vs Mississauga Lorne Park (ON) | 19:00:007:00 pm | N/A |
| Steubenville vs Pittsburgh Taylor Allderdice (PA) | 2019-08-29 19:00:00August 29, 2019 | Steubenville vs Pittsburgh Taylor Allderdice (PA) | 19:00:007:00 pm | N/A |
| Barnesville vs Buckeye Local | 2019-08-29 19:00:00August 29, 2019 |  Barnesville vs Buckeye Local | 19:00:007:00 pm | N/A |
| Navarre Fairless vs Sandy Valley | 2019-08-29 19:00:00August 29, 2019 | Navarre Fairless vs Sandy Valley | 19:00:007:00 pm | N/A |
| Caldwell vs Buckeye Trail | 2019-08-29 19:00:00August 29, 2019 |  Caldwell vs Buckeye Trail | 19:00:007:00 pm | N/A |
| Waverly vs Athens | 2019-08-30 19:00:00August 30, 2019 |   Waverly vs Athens | 19:00:007:00 pm | N/A |
| Coal Grove vs River Valley | 2019-08-30 19:00:00August 30, 2019 |   Coal Grove vs River Valley | 19:00:007:00 pm | N/A |
| Vinton County vs Unioto | 2019-08-30 19:00:00August 30, 2019 |   Vinton County vs Unioto | 19:00:007:00 pm | N/A |
| Meigs vs Gallia Academy | 2019-08-30 19:00:00August 30, 2019 |   Meigs vs Gallia Academy | 19:00:007:00 pm | N/A |
| South Gallia vs Symmes Valley | 2019-08-30 19:00:00August 30, 2019 |   South Gallia vs Symmes Valley | 19:00:007:00 pm | N/A |
| Notre Dame vs Southern | 2019-08-30 19:00:00August 30, 2019 |   Notre Dame vs Southern | 19:00:007:00 pm | N/A |
| Huntington vs Eastern Meigs | 2019-08-30 19:00:00August 30, 2019 |   Huntington vs Eastern Meigs | 19:00:007:00 pm | N/A |
| Hundred (WV) vs Federal Hocking | 2019-08-30 19:00:00August 30, 2019 |   Hundred (WV) vs Federal Hocking | 19:00:007:00 pm | N/A |
| Wahama WV vs Ravenswood WV | 2019-08-30 19:00:00August 30, 2019 |  Wahama WV vs Ravenswood WV | 19:00:007:00 pm | N/A |
| Sciotoville vs Waterford | 2019-08-30 19:00:00August 30, 2019 |   Sciotoville vs Waterford | 19:00:007:00 pm | N/A |
| Minford vs Rock Hill | 2019-08-30 19:00:00August 30, 2019 |   Minford vs Rock Hill | 19:00:007:00 pm | N/A |
| Chesapeake vs Oak Hill | 2019-08-30 19:00:00August 30, 2019 |   Chesapeake vs Oak Hill | 19:00:007:00 pm | N/A |
| Portsmouth West vs KIPP | 2019-08-30 19:00:00August 30, 2019 |  Portsmouth West vs KIPP | 19:00:007:00 pm | N/A |
| Paint Valley vs Beaver Eastern | 2019-08-30 19:00:00August 30, 2019 |   Paint Valley vs Beaver Eastern | 19:00:007:00 pm | N/A |
| Green vs Cincinnati Dohn | 2019-08-30 19:00:00August 30, 2019 |   Green vs Cincinnati Dohn | 19:00:007:00 pm | N/A |
| Southeastern vs Northwest | 2019-08-30 19:00:00August 30, 2019 |   Southeastern vs Northwest | 19:00:007:00 pm | N/A |
| Fairland vs Tolsia WV | 2019-08-30 19:00:00August 30, 2019 |  Fairland vs Tolsia WV | 19:00:007:00 pm | N/A |
| South Point vs Piketon | 2019-08-30 19:00:00August 30, 2019 |   South Point vs Piketon | 19:00:007:00 pm | N/A |
| McClain vs Adena | 2019-08-30 19:00:00August 30, 2019 |   McClain vs Adena | 19:00:007:00 pm | N/A |
| Hillsboro vs Western Brown | 2019-08-30 19:00:00August 30, 2019 |  Hillsboro vs Western Brown | 19:00:007:00 pm | N/A |
| Washington C.H. vs Blanchester | 2019-08-30 19:00:00August 30, 2019 |  Washington C.H. vs Blanchester | 19:00:007:00 pm | N/A |
| Madison Plains vs Westfall | 2019-08-30 19:00:00August 30, 2019 |  Madison Plains vs Westfall | 19:00:007:00 pm | N/A |
| West Holmes vs Wooster Triway | 2019-08-30 19:00:00August 30, 2019 | West Holmes vs Wooster Triway | 19:00:007:00 pm | N/A |
| Canal Fulton Northwest vs Claymont | 2019-08-30 19:00:00August 30, 2019 | Canal Fulton Northwest vs Claymont | 19:00:007:00 pm | N/A |
| East Liverpool vs Cleveland John F. Kennedy | 2019-08-30 19:00:00August 30, 2019 |  East Liverpool vs Cleveland John F. Kennedy | 19:00:007:00 pm | N/A |
| Cambridge vs Indian Creek | 2019-08-30 19:00:00August 30, 2019 |   Cambridge vs Indian Creek | 19:00:007:00 pm | N/A |
| Hanoverton United Local vs Minerva | 2019-08-30 19:00:00August 30, 2019 | Hanoverton United Local vs Minerva | 19:00:007:00 pm | N/A |
| River View vs Hebron Lakewood | 2019-08-30 19:00:00August 30, 2019 |  River View vs Hebron Lakewood | 19:00:007:00 pm | N/A |
| Carrollton vs St. Clairsville | 2019-08-30 19:00:00August 30, 2019 |  Carrollton vs St. Clairsville | 19:00:007:00 pm | N/A |
| Marengo Highland vs Bloom-Carroll | 2019-08-30 19:00:00August 30, 2019 |  Marengo Highland vs Bloom-Carroll | 19:00:007:00 pm | N/A |
| Beaver Local vs Leavittsburg LaBrae | 2019-08-30 19:00:00August 30, 2019 |  Beaver Local vs Leavittsburg LaBrae | 19:00:007:00 pm | N/A |
| Liberty Union vs Heath | 2019-08-30 19:00:00August 30, 2019 | Liberty Union vs Heath | 19:00:007:00 pm | N/A |
| Coshocton vs Indian Valley | 2019-08-30 19:00:00August 30, 2019 |  Coshocton vs Indian Valley | 19:00:007:00 pm | N/A |
| Edison Local vs Salineville Southern | 2019-08-30 19:00:00August 30, 2019 |  Edison Local vs Salineville Southern | 19:00:007:00 pm | N/A |
| Harrison Central vs Garaway | 2019-08-30 19:00:00August 30, 2019 |  Harrison Central vs Garaway | 19:00:007:00 pm | N/A |
| West Salem Northwestern vs Ridgewood | 2019-08-30 19:00:00August 30, 2019 | West Salem Northwestern vs Ridgewood | 19:00:007:00 pm | N/A |
| Apple Creek Waynedale vs Tuscarawas Valley | 2019-08-30 19:00:00August 30, 2019 | Apple Creek Waynedale vs Tuscarawas Valley | 19:00:007:00 pm | N/A |
| Bridgeport vs Weirton Madonna (WV) | 2019-08-30 19:00:00August 30, 2019 |   Bridgeport vs Weirton Madonna (WV) | 19:00:007:00 pm | N/A |
| Conotton Valley vs Strasburg | 2019-08-30 19:00:00August 30, 2019 |  Conotton Valley vs Strasburg | 19:00:007:00 pm | N/A |
| Shadyside vs Martins Ferry | 2019-08-30 19:00:00August 30, 2019 |   Shadyside vs Martins Ferry | 19:00:007:00 pm | N/A |
| Steubenville Catholic Central vs Africentric | 2019-08-30 19:00:00August 30, 2019 |  Steubenville Catholic Central vs Africentric | 19:00:007:00 pm | N/A |
| Toronto vs Wellsville | 2019-08-30 19:00:00August 30, 2019 | Toronto vs Wellsville | 19:00:007:00 pm | N/A |
| Teays Valley vs Chillicothe | 2019-08-30 19:00:00August 30, 2019 |   Teays Valley vs Chillicothe | 19:00:007:00 pm | N/A |
| Hamilton Township vs Columbus Franklin Heights | 2019-08-30 19:00:00August 30, 2019 |  Hamilton Township vs Columbus Franklin Heights | 19:00:007:00 pm | N/A |
| New Lexington vs Fairfield Union | 2019-08-30 19:00:00August 30, 2019 |   New Lexington vs Fairfield Union | 19:00:007:00 pm | N/A |
| Meadowbrook vs John Glenn | 2019-08-30 19:00:00August 30, 2019 |   Meadowbrook vs John Glenn | 19:00:007:00 pm | N/A |
| Philo vs Jonathon Alder | 2019-08-30 19:00:00August 30, 2019 |  Philo vs Jonathon Alder | 19:00:007:00 pm | N/A |
| Sheridan vs Licking Valley | 2019-08-30 19:00:00August 30, 2019 |  Sheridan vs Licking Valley | 19:00:007:00 pm | N/A |
| Tri-Valley vs Logan | 2019-08-30 19:00:00August 30, 2019 |   Tri-Valley vs Logan | 19:00:007:00 pm | N/A |
| New Philadelphia vs Maysville | 2019-08-30 19:00:00August 30, 2019 |   New Philadelphia vs Maysville | 19:00:007:00 pm | N/A |
| Circleville vs Miami Trace | 2019-08-30 19:00:00August 30, 2019 |   Circleville vs Miami Trace | 19:00:007:00 pm | N/A |
| Zanesville vs Newark | 2019-08-30 19:00:00August 30, 2019 |  Zanesville vs Newark | 19:00:007:00 pm | N/A |
| Logan Elm vs Zane Trace | 2019-08-30 19:00:00August 30, 2019 |   Logan Elm vs Zane Trace | 19:00:007:00 pm | N/A |
| Miller vs Beallsville | 2019-08-30 19:00:00August 30, 2019 |   Miller vs Beallsville | 19:00:007:00 pm | N/A |
