| 2021-03-27 12:48:07March 27, 2021 | Peebles  | 2 - 10 |  Clay | N/A | Recap |
| 2021-03-27 12:55:50March 27, 2021 | Clay | 2 - 8 |  Northwest | N/A | Recap |
| 2021-03-27 13:21:27March 27, 2021 | Miami Trace  | 13 - 1 | Legacy Christian Academy | N/A | Recap |
| 2021-03-27 14:00:00March 27, 2021 | South Webster  | 5 - 4 |  Southeastern | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Trimble  | 10 - 13 |  Nelsonville-York | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Trimble | 5 - 3 | Nelsonville-York | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Federal Hocking  | 2 - 4 |  Crooksville | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Federal Hocking | 14 - 4 | Crooksville | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Paint Valley  | 6 - 4 |  Vinton County | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Paint Valley | 7 - 0 | Vinton County | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | River Valley  | 4 - 2 |  Rock Hill | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Fairfield Union  | 9 - 2 |  Logan | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Warren  | 10 - 0 |  Meigs | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Warren | 5 - 1 | Meigs | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Chesapeake  | 2 - 5 |  Wellston | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Piketon  | 7 - 8 |  Oak Hill | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Piketon | 17 - 7 | Oak Hill | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Meadowbrook | 8 - 4 |  Marietta | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Waverly  | 6 - 5 |  Circleville | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Fairfield Union | 14 - 0 | Logan | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Portsmouth West  | 6 - 3 |  South Point | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Fairland  | 7 - 0 |  Green | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Canal Winchester | 12 - 3 |  Zane Trace | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Buckeye Valley | 8 - 1 |  Westfall | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Jackson  | 16 - 6 |  Gallia Academy | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Morgan | 13 - 0 |  Waterford | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Northwest | 1 - 6 | Peebles | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Wheelersburg  | 3 - 6 | Hilliard Darby | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Symmes Valley  | 12 - 0 |  South Gallia | N/A | Recap |
| 2021-03-27 14:30:00March 27, 2021 | Morgan | 8 - 7 | Waterford | N/A | Recap |
| 2021-03-27 15:12:31March 27, 2021 | Western  | 3 - 12 |  St. Joseph | N/A | Recap |
| 2021-03-27 16:18:47March 27, 2021 | Ironton  | 7 - 5 |  Valley | N/A | Recap |
| 2021-03-27 16:44:22March 27, 2021 | Coal Grove  | 1 - 8 |  Notre Dame | N/A | Recap |
| 2021-03-27 17:50:05March 27, 2021 | Adena  | 2 - 8 |  Hillsboro | N/A | Recap |
| 2021-03-27 18:07:19March 27, 2021 | Ripley  | 0 - 10 | Felicity-Franklin | N/A | Recap |
| 2021-03-29 11:27:09March 29, 2021 | Morgan | 9 - 2 | West Muskingum | N/A | Recap |
| 2021-03-29 11:30:24March 29, 2021 | Waverly | 3 - 0 | Portsmouth West | N/A | Recap |
| 2021-03-29 11:32:15March 29, 2021 | Fairland | 11 - 1 | River Valley | N/A | Recap |
| 2021-03-29 11:34:02March 29, 2021 | Valley | 3 - 2 | South Webster | N/A | Recap |
| 2021-03-29 11:35:55March 29, 2021 | Greenup County (KY) | 16 - 1 | South Point | N/A | Recap |
| 2021-03-29 11:37:07March 29, 2021 | Zane Trace | 10 - 9 |  Washington | N/A | Recap |
| 2021-03-29 11:38:47March 29, 2021 | Marietta | 9 - 6 | Zanesville | N/A | Recap |
| 2021-03-29 11:39:50March 29, 2021 | Oak Hill | 14 - 3 | Northwest | N/A | Recap |
| 2021-03-29 11:41:38March 29, 2021 | Eastern Meigs  | 6 - 5 |  Fort Frye | N/A | Recap |
| 2021-03-29 11:57:48March 29, 2021 | Southeastern | 15 - 4 |  North Adams | N/A | Recap |
| 2021-03-29 11:59:48March 29, 2021 | Hillsboro | 7 - 3 |  Unioto | N/A | Recap |
| 2021-03-29 12:02:09March 29, 2021 | Federal Hocking | 14 - 1 |  Miller | N/A | Recap |
| 2021-03-29 12:04:21March 29, 2021 | Waterford | 10 - 6 |  Caldwell | N/A | Recap |
| 2021-03-29 12:11:47March 29, 2021 | Cambridge | 13 - 3 | Steubenville Central | N/A | Recap |
| 2021-03-29 12:20:01March 29, 2021 | Fayetteville-Perry  | 8 - 9 | East Clinton | N/A | Recap |
| 2021-03-29 14:00:00March 29, 2021 | Hilliard Davidson | 13 - 1 |  Chillicothe | N/A | Recap |
| 2021-03-29 14:00:00March 29, 2021 | Crooksville | 5 - 1 | Coshocton | N/A | Recap |
| 2021-03-29 14:00:00March 29, 2021 | Clay | 10 - 0 |  Manchester | N/A | Recap |
| 2021-03-29 14:00:00March 29, 2021 | Meadowbrook | 10 - 2 |  New Lexington | N/A | Recap |
| 2021-03-29 14:00:00March 29, 2021 | Lewis County (KY) | 0 - 2 | Notre Dame | N/A | Recap |
| 2021-03-29 14:00:00March 29, 2021 | McClain  | 0 - 6 | Piketon | N/A | Recap |
| 2021-03-29 14:00:00March 29, 2021 | Tri-Valley | 5 - 4 |  Sheridan | N/A | Recap |
| 2021-03-29 14:19:33March 29, 2021 | Nelsonville-York | 2 - 4 |  Southern | N/A | Recap |
| 2021-03-29 14:39:38March 29, 2021 | Vinton County | 10 - 4 | Trimble | N/A | Recap |
| 2021-03-29 14:50:28March 29, 2021 | Sciotoville  | 2 - 15 | Paint Valley | N/A | Recap |
| 2021-03-29 15:28:51March 29, 2021 | Minford  | 11 - 0 |  Beaver Eastern | N/A | Recap |
| 2021-03-29 16:20:12March 29, 2021 | Ironton | 9 - 0 | Wellston | N/A | Recap |
| 2021-03-29 16:21:01March 29, 2021 | Fairfield Union | 2 - 12 | Watkins Memorial | N/A | Recap |
| 2021-03-29 16:54:41March 29, 2021 | Rock Hill | 18 - 1 | Green | N/A | Recap |
| 2021-03-29 17:12:45March 29, 2021 | Westfall | 4 - 0 |  Logan Elm | N/A | Recap |
| 2021-03-29 18:18:45March 29, 2021 | Huntington  | 7 - 2 |  Alexander | N/A | Recap |
| 2021-03-29 20:55:21March 29, 2021 | Southern | 4 - 2 | Nelsonville-York | N/A | Recap |
| 2021-03-29 21:04:01March 29, 2021 | Trimble | 4 - 10 | Vinton County | N/A | Recap |
| 2021-03-30 12:14:34March 30, 2021 | Wheelersburg | 7 - 2 | Ironton | N/A | Recap |
| 2021-03-30 12:16:59March 30, 2021 | Federal Hocking | 7 - 6 | Alexander | N/A | Recap |
| 2021-03-30 12:26:25March 30, 2021 | Paint Valley | 22 - 4 | Western | N/A | Recap |
| 2021-03-30 12:32:54March 30, 2021 | Thomas Worthington | 9 - 1 | Chillicothe | N/A | Recap |
| 2021-03-30 12:33:13March 30, 2021 | Waverly | 8 - 6 | Huntington | N/A | Recap |
| 2021-03-30 12:34:47March 30, 2021 | Warren | 3 - 2 | Fort Frye | N/A | Recap |
| 2021-03-30 12:36:07March 30, 2021 | Marietta | 6 - 5 | Logan | N/A | Recap |
| 2021-03-30 12:37:13March 30, 2021 | Athens  | 6 - 5 | Gallia Academy | N/A | Recap |
| 2021-03-30 12:39:37March 30, 2021 | Jackson | 4 - 2 | Adena | N/A | Recap |
| 2021-03-30 12:39:55March 30, 2021 | Meigs | 5 - 11 | Waterford | N/A | Recap |
| 2021-03-30 12:41:40March 30, 2021 | Unioto | 5 - 2 | Washington | N/A | Recap |
| 2021-03-30 12:44:05March 30, 2021 | Circleville | 6 - 4 | Hillsboro | N/A | Recap |
| 2021-03-30 12:46:56March 30, 2021 | Portsmouth  | 14 - 3 | Oak Hill | N/A | Recap |
| 2021-03-30 12:49:25March 30, 2021 | St. Joseph | 4 - 3 | River Valley | N/A | Recap |
| 2021-03-30 12:52:14March 30, 2021 | Cambridge | 3 - 2 | Meadowbrook | N/A | Recap |
| 2021-03-30 13:23:23March 30, 2021 | Miami Trace | 16 - 0 | Briggs | N/A | Recap |
| 2021-03-30 14:00:00March 30, 2021 | Sciotoville | 0 - 11 | Beaver Eastern | N/A | Recap |
| 2021-03-30 14:00:00March 30, 2021 | Peebles | 7 - 6 |  Eastern Brown | N/A | Recap |
| 2021-03-30 14:00:00March 30, 2021 | New Lexington | 8 - 7 | Morgan | N/A | Recap |
| 2021-03-30 14:00:00March 30, 2021 | South Gallia | 0 - 11 | Notre Dame | N/A | Recap |
| 2021-03-30 15:07:12March 30, 2021 | Fairfield Union | 11 - 1 | Fisher Catholic | N/A | Recap |
| 2021-03-30 15:08:00March 30, 2021 | Fairfield Union | 12 - 15 | Lakewood | N/A | Recap |
| 2021-03-30 15:49:12March 30, 2021 | South Webster | 1 - 11 | Wellston | N/A | Recap |
| 2021-03-30 16:29:54March 30, 2021 | Chesapeake | 14 - 10 | Northwest | N/A | Recap |
| 2021-03-30 16:58:46March 30, 2021 | Rock Hill | 4 - 10 | Symmes Valley | N/A | Recap |
| 2021-03-30 17:14:01March 30, 2021 | South Point | 2 - 13 | Grace Christian | N/A | Recap |
| 2021-03-30 17:41:57March 30, 2021 | Lynchburg-Clay  | 7 - 4 |  Fairfield | N/A | Recap |
| 2021-03-30 17:46:19March 30, 2021 | Whiteoak  | 2 - 3 | North Adams | N/A | Recap |
| 2021-03-30 18:09:12March 30, 2021 | Ripley | 0 - 18 | Fayetteville-Perry | N/A | Recap |
| 2021-03-30 18:17:45March 30, 2021 | Manchester | 12 - 0 |  West Union | N/A | Recap |
| 2021-03-30 18:27:23March 30, 2021 | Southeastern | 16 - 5 | Green | N/A | Recap |
| 2021-03-30 18:32:45March 30, 2021 | Eastern Meigs | 6 - 6 | Vinton County | N/A | Recap |
| 2021-03-30 20:56:40March 30, 2021 | Southern | 12 - 6 | Miller | N/A | Recap |
| 2021-03-31 12:53:40March 31, 2021 | Wheelersburg | 9 - 0 | Valley | N/A | Recap |
| 2021-03-31 12:54:38March 31, 2021 | Waverly | 3 - 0 | South Webster | N/A | Recap |
| 2021-03-31 12:56:11March 31, 2021 | Unioto | 10 - 7 | Logan | N/A | Recap |
| 2021-03-31 12:57:15March 31, 2021 | Whiteoak | 2 - 1 | Paint Valley | N/A | Recap |
| 2021-03-31 12:58:17March 31, 2021 | Lebanon | 10 - 0 | Adena | N/A | Recap |
| 2021-03-31 12:59:33March 31, 2021 | Miami Trace | 10 - 8 | Circleville | N/A | Recap |
| 2021-03-31 13:33:14March 31, 2021 | McClain | 2 - 6 | Westfall | N/A | Recap |
| 2021-03-31 14:00:00March 31, 2021 | Sheridan | 5 - 4 | Philo | N/A | Recap |
| 2021-03-31 14:34:21March 31, 2021 | Notre Dame | 12 - 1 | Western | N/A | Recap |
| 2021-03-31 15:07:35March 31, 2021 | Washington | 7 - 0 | Piketon | N/A | Recap |
| 2021-03-31 15:31:22March 31, 2021 | Minford | 10 - 0 | Oak Hill | N/A | Recap |
| 2021-04-01 12:50:24April 1, 2021 | Peebles | 11 - 12 | Piketon | N/A | Recap |
| 2021-04-01 13:16:11April 1, 2021 | Hillsboro | 20 - 6 | East Clinton | N/A | Recap |
| 2021-04-01 14:00:00April 1, 2021 | Whiteoak | 4 - 1 | Georgetown | N/A | Recap |
| 2021-04-01 14:00:00April 1, 2021 | River View | 3 - 2 | New Lexington | N/A | Recap |
| 2021-04-01 17:15:51April 1, 2021 | South Point | 12 - 18 | Fairview | N/A | Recap |
| 2021-04-02 12:56:53April 2, 2021 | Clay | 15 - 0 | Green | N/A | Recap |
| 2021-04-02 14:00:00April 2, 2021 | Nelsonville-York | 0 - 12 | Crooksville | N/A | Recap |
| 2021-04-02 14:00:00April 2, 2021 | Raceland (KY) | 14 - 4 | Fairland | N/A | Recap |
| 2021-04-02 14:00:00April 2, 2021 | Symmes Valley | 18 - 6 | Western | N/A | Recap |
| 2021-04-02 15:37:03April 2, 2021 | Minford | 7 - 11 | South Webster | N/A | Recap |
| 2021-04-02 15:55:03April 2, 2021 | Valley | 9 - 2 | Northwest | N/A | Recap |
| 2021-04-02 16:29:54April 2, 2021 | Beaver Eastern | 2 - 12 | Oak Hill | N/A | Recap |
| 2021-04-02 17:43:01April 2, 2021 | Batavia | 24 - 3 | Lynchburg-Clay | N/A | Recap |
| 2021-04-02 18:10:52April 2, 2021 | Ripley | 7 - 12 | Bracken County | N/A | Recap |
| 2021-04-02 20:54:50April 2, 2021 | Warren | 30 - 0 | Logan | N/A | Recap |
| 2021-04-02 20:55:49April 2, 2021 | Wheelersburg | 9 - 2 | Portsmouth West | N/A | Recap |
| 2021-04-02 20:56:53April 2, 2021 | Russell (KY) | 5 - 3 | Ironton | N/A | Recap |
| 2021-04-02 20:57:59April 2, 2021 | Athens | 12 - 10 | Waterford | N/A | Recap |
| 2021-04-02 21:00:28April 2, 2021 | Pickerington Central | 9 - 5 | Adena | N/A | Recap |
| 2021-04-02 21:01:23April 2, 2021 | Liberty Union | 10 - 0 | Westfall | N/A | Recap |
| 2021-04-02 21:02:14April 2, 2021 | Amanda-Clearcreek | 10 - 0 | Zane Trace | N/A | Recap |
| 2021-04-02 21:02:59April 2, 2021 | McClain | 4 - 1 | Fairfield | N/A | Recap |
| 2021-04-03 08:32:50April 3, 2021 | Portsmouth | 10 - 0 | Clay | N/A | Recap |
| 2021-04-03 08:34:21April 3, 2021 | Whiteoak | 7 - 2 | Oak Hill | N/A | Recap |
| 2021-04-03 08:36:12April 3, 2021 | Hillsboro | 3 - 2 | Whiteoak | N/A | Recap |
| 2021-04-03 08:37:24April 3, 2021 | River Valley | 6 - 0 | Waterford | N/A | Recap |
| 2021-04-03 08:38:25April 3, 2021 | Chillicothe | 5 - 4 | Waverly | N/A | Recap |
| 2021-04-03 08:40:09April 3, 2021 | Logan Elm | 6 - 1 | Zane Trace | N/A | Recap |
| 2021-04-03 08:41:31April 3, 2021 | Jackson | 11 - 1 | Warren | N/A | Recap |
| 2021-04-03 08:42:27April 3, 2021 | Wheelersburg | 8 - 4 |  Fort Loramie | N/A | Recap |
| 2021-04-03 08:44:00April 3, 2021 | Portsmouth West | 11 - 1 | Coal Grove | N/A | Recap |
| 2021-04-03 08:45:34April 3, 2021 | Cambridge | 6 - 5 | Maysville | N/A | Recap |
| 2021-04-03 08:46:32April 3, 2021 | Cambridge | 5 - 1 | Maysville | N/A | Recap |
| 2021-04-03 09:22:57April 3, 2021 | Athens | 2 - 7 | Amanda-Clearcreek | N/A | Recap |
| 2021-04-03 12:05:35April 3, 2021 | Jackson | 7 - 4 | Minford | N/A | Recap |
| 2021-04-03 14:00:00April 3, 2021 | Beallsville | 0 - 19 | Federal Hocking | N/A | Recap |
| 2021-04-03 14:00:00April 3, 2021 | Frontier  | 4 - 3 | Federal Hocking | N/A | Recap |
| 2021-04-03 14:00:00April 3, 2021 | Trimble | 0 - 13 | Hillsboro | N/A | Recap |
| 2021-04-03 14:00:00April 3, 2021 | Miami Trace | 10 - 0 | Manchester | N/A | Recap |
| 2021-04-03 14:00:00April 3, 2021 | Felicity-Franklin | 14 - 0 | West Union | N/A | Recap |
| 2021-04-03 14:00:00April 3, 2021 | North Adams | 15 - 5 | Western | N/A | Recap |
| 2021-04-03 14:00:00April 3, 2021 | Miami Trace | 14 - 2 | Manchester | N/A | Recap |
| 2021-04-03 14:40:54April 3, 2021 | Vinton County | 3 - 16 | Heath | N/A | Recap |
| 2021-04-03 15:21:48April 3, 2021 | Logan | 0 - 19 | Sheridan | N/A | Recap |
| 2021-04-03 15:22:39April 3, 2021 | Logan | 0 - 12 | Sheridan | N/A | Recap |
| 2021-04-03 15:39:07April 3, 2021 | Minford | 9 - 3 | Warren | N/A | Recap |
| 2021-04-03 15:56:45April 3, 2021 | Valley | 5 - 1 | Piketon | N/A | Recap |
| 2021-04-03 17:02:24April 3, 2021 | Whiteoak | 7 - 2 | Rock Hill | N/A | Recap |
| 2021-04-03 17:03:24April 3, 2021 | Rock Hill | 2 - 1 | Trimble | N/A | Recap |
| 2021-04-03 18:18:52April 3, 2021 | West Union | 2 - 11 | Felicity-Franklin | N/A | Recap |
| 2021-04-03 20:28:00April 3, 2021 | Circleville | 11 - 4 | Washington | N/A | Recap |
| 2021-04-03 21:05:04April 3, 2021 | Trimble | 0 - 12 | Rock Hill | N/A | Recap |
| 2021-04-05 08:47:48April 5, 2021 | Chesapeake | 1 - 11 | Portsmouth | N/A | Recap |
| 2021-04-05 08:52:00April 5, 2021 | Jackson | 14 - 4 | Valley | N/A | Recap |
| 2021-04-05 08:53:35April 5, 2021 | Fairland | 7 - 2 | Ironton | N/A | Recap |
| 2021-04-05 08:57:08April 5, 2021 | Gallia Academy | 17 - 2 | South Point | N/A | Recap |
| 2021-04-05 09:02:37April 5, 2021 | Waterford | 10 - 1 | Federal Hocking | N/A | Recap |
| 2021-04-05 09:06:52April 5, 2021 | Wheelersburg | 6 - 2 | Oak Hill | N/A | Recap |
| 2021-04-05 09:10:29April 5, 2021 | Unioto | 4 - 2 | Paint Valley | N/A | Recap |
| 2021-04-05 09:12:44April 5, 2021 | Adena | 4 - 1 | Zane Trace | N/A | Recap |
| 2021-04-05 09:14:11April 5, 2021 | Piketon | 12 - 1 | Southeastern | N/A | Recap |
| 2021-04-05 09:15:15April 5, 2021 | Westfall | 3 - 2 | Huntington | N/A | Recap |
| 2021-04-05 09:16:33April 5, 2021 | Portsmouth West | 7 - 2 | Northwest | N/A | Recap |
| 2021-04-05 09:19:15April 5, 2021 | Dover | 11 - 0 | Marietta | N/A | Recap |
| 2021-04-05 09:20:25April 5, 2021 | Cambridge | 5 - 4 | Warren | N/A | Recap |
| 2021-04-05 09:21:28April 5, 2021 | Athens | 15 - 1 | Nelsonville-York | N/A | Recap |
| 2021-04-05 13:36:02April 5, 2021 | McClain | 7 - 6 | Peebles | N/A | Recap |
| 2021-04-05 14:00:00April 5, 2021 | Hamilton Township | 0 - 11 | Circleville | N/A | Recap |
| 2021-04-05 14:00:00April 5, 2021 | Fairfield Union | 5 - 4 | Liberty Union | N/A | Recap |
| 2021-04-05 14:00:00April 5, 2021 | Teays Valley | 2 - 8 | Logan Elm | N/A | Recap |
| 2021-04-05 14:00:00April 5, 2021 | Rosecrans | 10 - 0 | Miller | N/A | Recap |
| 2021-04-05 14:00:00April 5, 2021 | Crooksville | 2 - 3 | New Lexington | N/A | Recap |
| 2021-04-05 14:00:00April 5, 2021 | Green | 18 - 1 | Sciotoville | N/A | Recap |
| 2021-04-05 14:00:00April 5, 2021 | Meigs | 9 - 0 | Alexander | N/A | Recap |
| 2021-04-05 14:36:22April 5, 2021 | Notre Dame | 3 - 4 | Symmes Valley | N/A | Recap |
| 2021-04-05 14:42:50April 5, 2021 | Vinton County | 9 - 0 | Wellston | N/A | Recap |
| 2021-04-05 15:08:24April 5, 2021 | Washington | 8 - 1 | Fairfield | N/A | Recap |
| 2021-04-05 15:43:40April 5, 2021 | Minford | 4 - 0 | Waverly | N/A | Recap |
| 2021-04-05 16:31:09April 5, 2021 | Beaver Eastern | 6 - 10 | South Webster | N/A | Recap |
| 2021-04-05 17:06:06April 5, 2021 | Rock Hill | 9 - 0 | Coal Grove | N/A | Recap |
| 2021-04-05 18:40:14April 5, 2021 | Williamsburg | 4 - 0 | Whiteoak | N/A | Recap |
| 2021-04-05 18:42:28April 5, 2021 | Eastern Meigs | 12 - 0 | South Gallia | N/A | Recap |
| 2021-04-05 21:06:23April 5, 2021 | Trimble | 1 - 5 |  Belpre | N/A | Recap |
| 2021-04-06 12:26:24April 6, 2021 | Fayetteville-Perry | 7 - 12 | Lynchburg-Clay | N/A | Recap |
| 2021-04-06 12:40:04April 6, 2021 | Manchester | 8 - 4 | Eastern Brown | N/A | Recap |
| 2021-04-06 12:58:31April 6, 2021 | Clay | 16 - 2 | South Webster | N/A | Recap |
| 2021-04-06 13:27:45April 6, 2021 | Miami Trace | 12 - 2 | Logan Elm | N/A | Recap |
| 2021-04-06 13:37:04April 6, 2021 | McClain | 11 - 1 | Green | N/A | Recap |
| 2021-04-06 14:00:00April 6, 2021 | West Muskingum | 6 - 8 | Crooksville | N/A | Recap |
| 2021-04-06 14:00:00April 6, 2021 | Waterford | - | Fort Frye | N/A | Recap |
| 2021-04-06 14:00:00April 6, 2021 | Miller | 2 - 4 | Southern | N/A | Recap |
| 2021-04-06 15:24:39April 6, 2021 | Washington | 8 - 5 | Westfall | N/A | Recap |
| 2021-04-06 15:52:36April 6, 2021 | Portsmouth | 14 - 4 | Portsmouth West | N/A | Recap |
| 2021-04-06 16:21:52April 6, 2021 | Ironton | 12 - 7 | St. Joseph | N/A | Recap |
| 2021-04-06 16:36:59April 6, 2021 | Coshocton | 2 - 7 | Sheridan | N/A | Recap |
| 2021-04-06 16:39:20April 6, 2021 | Northwest | 7 - 12 | Huntington | N/A | Recap |
| 2021-04-06 16:54:53April 6, 2021 | Oak Hill | 9 - 4 | River Valley | N/A | Recap |
| 2021-04-06 17:17:36April 6, 2021 | South Point | 20 - 19 | South Gallia | N/A | Recap |
| 2021-04-06 17:25:59April 6, 2021 | Unioto | 15 - 19 | Jackson | N/A | Recap |
| 2021-04-06 18:00:34April 6, 2021 | North Adams | 2 - 4 | Fairfield | N/A | Recap |
| 2021-04-06 18:11:55April 6, 2021 | Peebles | 16 - 3 | Ripley | N/A | Recap |
| 2021-04-06 18:20:16April 6, 2021 | West Union | 0 - 24 | Whiteoak | N/A | Recap |
| 2021-04-06 20:16:00April 6, 2021 | Belpre | 7 - 6 | Alexander | N/A | Recap |
| 2021-04-06 20:22:39April 6, 2021 | Beaver Eastern | 7 - 6 | Western | N/A | Recap |
| 2021-04-07 09:24:21April 7, 2021 | Marietta | 10 - 8 | New Philadelphia | N/A | Recap |
| 2021-04-07 09:31:50April 7, 2021 | Adena | 9 - 2 | Huntington | N/A | Recap |
| 2021-04-07 09:32:57April 7, 2021 | Zane Trace | 10 - 0 | Southeastern | N/A | Recap |
| 2021-04-07 09:34:01April 7, 2021 | Unioto | 5 - 2 | Piketon | N/A | Recap |
| 2021-04-07 09:36:15April 7, 2021 | Westfall | 11 - 0 | Paint Valley | N/A | Recap |
| 2021-04-07 09:37:12April 7, 2021 | Minford | 4 - 3 | Portsmouth West | N/A | Recap |
| 2021-04-07 09:39:52April 7, 2021 | Wheelersburg | 5 - 1 | Northwest | N/A | Recap |
| 2021-04-07 09:42:42April 7, 2021 | Beaver Eastern | 0 - 10 | Valley | N/A | Recap |
| 2021-04-07 09:47:33April 7, 2021 | Waverly | 7 - 2 | Oak Hill | N/A | Recap |
| 2021-04-07 09:48:38April 7, 2021 | Portsmouth | 14 - 2 | South Point | N/A | Recap |
| 2021-04-07 09:50:42April 7, 2021 | Fairland | 6 - 2 | Rock Hill | N/A | Recap |
| 2021-04-07 09:53:37April 7, 2021 | Ironton | 14 - 4 | Coal Grove | N/A | Recap |
| 2021-04-07 09:54:46April 7, 2021 | Clay | 31 - 1 | Western | N/A | Recap |
| 2021-04-07 09:56:10April 7, 2021 | St. Joseph | 14 - 4 | South Gallia | N/A | Recap |
| 2021-04-07 09:58:43April 7, 2021 | Athens | 10 - 2 | Wellston | N/A | Recap |
| 2021-04-07 12:36:20April 7, 2021 | Chillicothe | 3 - 5 | Hillsboro | N/A | Recap |
| 2021-04-07 12:41:06April 7, 2021 | Manchester | 4 - 2 | Peebles | N/A | Recap |
| 2021-04-07 13:38:22April 7, 2021 | McClain | 0 - 2 | Washington | N/A | Recap |
| 2021-04-07 13:56:29April 7, 2021 | Alexander | 0 - 4 | River Valley | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Waterford | 18 - 11 | Belpre | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | New Lexington | 4 - 3 | Coshocton | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Morgan | 8 - 13 | Crooksville | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Circleville | 1 - 4 | Fairfield Union | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Miami Trace | 1 - 13 | Jackson | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Sheridan | 2 - 1 | Maysville | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Miller | 2 - 12 | Millersport | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Lewis County (KY) | 8 - 9 | Notre Dame | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | St. Joseph | 11 - 4 | South Gallia | N/A | Recap |
| 2021-04-07 14:00:00April 7, 2021 | Sciotoville | 0 - 18 | Symmes Valley | N/A | Recap |
| 2021-04-07 14:22:14April 7, 2021 | Nelsonville-York | 2 - 12 | Logan | N/A | Recap |
| 2021-04-07 14:43:37April 7, 2021 | Vinton County | 4 - 7 | Meigs | N/A | Recap |
| 2021-04-07 16:01:22April 7, 2021 | Gallia Academy | 2 - 6 | Chesapeake | N/A | Recap |
| 2021-04-07 18:43:40April 7, 2021 | Eastern Meigs | 9 - 10 | Trimble | N/A | Recap |
| 2021-04-07 20:36:12April 7, 2021 | Federal Hocking | 0 - 5 | Southern | N/A | Recap |
| 2021-04-08 14:00:00April 8, 2021 | New Lexington | 0 - 3 | John Glenn | N/A | Recap |
| 2021-04-08 14:00:00April 8, 2021 | Meadowbrook | 4 - 2 | Sheridan | N/A | Recap |
| 2021-04-08 14:26:32April 8, 2021 | Green | 1 - 11 | St. Joseph | N/A | Recap |
| 2021-04-08 15:53:48April 8, 2021 | South Webster | 28 - 1 | Sciotoville | N/A | Recap |
| 2021-04-08 17:09:10April 8, 2021 | Rock Hill | 4 - 3 | Notre Dame | N/A | Recap |
| 2021-04-09 11:56:43April 9, 2021 | Athens | 0 - 3 | Meigs | N/A | Recap |
| 2021-04-09 12:06:15April 9, 2021 | Warren | 8 - 3 | Marietta | N/A | Recap |
| 2021-04-09 12:07:27April 9, 2021 | Eastern Meigs | 10 - 0 | Waterford | N/A | Recap |
| 2021-04-09 12:08:27April 9, 2021 | Westfall | 5 - 0 | Piketon | N/A | Recap |
| 2021-04-09 12:09:51April 9, 2021 | Zane Trace | 6 - 2 | Huntington | N/A | Recap |
| 2021-04-09 12:11:53April 9, 2021 | Paint Valley | 5 - 4 | Adena | N/A | Recap |
| 2021-04-09 12:12:39April 9, 2021 | Unioto | 16 - 4 | Southeastern | N/A | Recap |
| 2021-04-09 12:14:45April 9, 2021 | Fairland | 11 - 1 | South Point | N/A | Recap |
| 2021-04-09 12:15:36April 9, 2021 | Minford | 6 - 2 | Wheelersburg | N/A | Recap |
| 2021-04-09 12:18:18April 9, 2021 | Valley | 12 - 0 | Portsmouth West | N/A | Recap |
| 2021-04-09 12:19:23April 9, 2021 | Jackson | 11 - 0 | McClain | N/A | Recap |
| 2021-04-09 12:27:54April 9, 2021 | Fayetteville-Perry | 4 - 6 | Manchester | N/A | Recap |
| 2021-04-09 12:38:14April 9, 2021 | Chillicothe | 3 - 9 | Miami Trace | N/A | Recap |
| 2021-04-09 12:59:50April 9, 2021 | Clay | 11 - 6 | Symmes Valley | N/A | Recap |
| 2021-04-09 14:00:00April 9, 2021 | Fairfield Union | 8 - 9 | Amanda-Clearcreek | N/A | Recap |
| 2021-04-09 14:00:00April 9, 2021 | Teays Valley | 9 - 8 | Circleville | N/A | Recap |
| 2021-04-09 14:00:00April 9, 2021 | Philo | 12 - 2 | Crooksville | N/A | Recap |
| 2021-04-09 14:00:00April 9, 2021 | Belpre | 1 - 15 | Fort Frye | N/A | Recap |
| 2021-04-09 14:00:00April 9, 2021 | Hamilton Township | 4 - 11 | Logan Elm | N/A | Recap |
| 2021-04-09 14:00:00April 9, 2021 | Berne Union | 16 - 2 | Miller | N/A | Recap |
| 2021-04-09 14:05:11April 9, 2021 | Alexander | 8 - 13 | Wellston | N/A | Recap |
| 2021-04-09 14:22:55April 9, 2021 | Nelsonville-York | - | River Valley | N/A | Recap |
| 2021-04-09 14:27:37April 9, 2021 | Green | 6 - 1 | Western | N/A | Recap |
| 2021-04-09 14:44:35April 9, 2021 | Vinton County | 1 - 3 | Logan | N/A | Recap |
| 2021-04-09 14:46:11April 9, 2021 | Notre Dame | 11 - 1 | Sciotoville | N/A | Recap |
| 2021-04-09 15:29:01April 9, 2021 | Washington | 0 - 5 | Hillsboro | N/A | Recap |
| 2021-04-09 15:47:16April 9, 2021 | Portsmouth | 3 - 7 | Rock Hill | N/A | Recap |
| 2021-04-09 16:02:20April 9, 2021 | Gallia Academy | 4 - 7 | Ironton | N/A | Recap |
| 2021-04-09 16:37:01April 9, 2021 | Beaver Eastern | 0 - 8 | Waverly | N/A | Recap |
| 2021-04-09 16:49:37April 9, 2021 | Northwest | 4 - 2 | South Webster | N/A | Recap |
| 2021-04-09 17:34:27April 9, 2021 | Eastern Brown | 22 - 2 | Ripley | N/A | Recap |
| 2021-04-09 17:44:21April 9, 2021 | Lynchburg-Clay | 31 - 0 | West Union | N/A | Recap |
| 2021-04-09 18:01:44April 9, 2021 | North Adams | 2 - 7 | Peebles | N/A | Recap |
| 2021-04-09 18:29:02April 9, 2021 | Whiteoak | 3 - 0 | Fairfield | N/A | Recap |
| 2021-04-09 21:00:12April 9, 2021 | Southern | 12 - 2 | Trimble | N/A | Recap |
| 2021-04-10 12:39:41April 10, 2021 | Chillicothe | 2 - 5 | Wheelersburg | N/A | Recap |
| 2021-04-10 13:30:43April 10, 2021 | Miami Trace | 8 - 6 | Urbana | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Belpre | 4 - 1 | Caldwell | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Circleville | 6 - 7 | Canal Winchester | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Western Brown | 11 - 13 | Hillsboro | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | New Lexington | 16 - 1 | Logan | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | New Lexington | 11 - 1 | Logan | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Crooksville | 19 - 1 | Miller | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Manchester | 17 - 2 | Sciotoville | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Amanda-Clearcreek | 4 - 3 | Sheridan | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Fairview (KY) | 5 - 8 | Portsmouth West | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Crooksville | 16 - 6 | Miller | N/A | Recap |
| 2021-04-10 14:00:00April 10, 2021 | Amanda-Clearcreek | 1 - 21 | Sheridan | N/A | Recap |
| 2021-04-10 15:00:44April 10, 2021 | Chillicothe | 3 - 9 | Wheelersburg | N/A | Recap |
| 2021-04-10 15:02:30April 10, 2021 | Sciotoville | 2 - 12 | Manchester | N/A | Recap |
| 2021-04-10 16:05:46April 10, 2021 | Gallia Academy | 1 - 12 | Warren | N/A | Recap |
| 2021-04-10 16:06:11April 10, 2021 | Gallia Academy | 5 - 8 | Warren | N/A | Recap |
| 2021-04-10 16:20:30April 10, 2021 | South Webster | 14 - 0 | Whiteoak | N/A | Recap |
| 2021-04-10 16:20:30April 10, 2021 | South Webster | 5 - 6 | Whiteoak | N/A | Recap |
| 2021-04-10 16:24:26April 10, 2021 | Ironton | 8 - 3 | Adena | N/A | Recap |
| 2021-04-10 16:42:55April 10, 2021 | Coal Grove | 3 - 6 | Chesapeake | N/A | Recap |
| 2021-04-10 17:46:13April 10, 2021 | Bethel Tate | 21 - 10 | Lynchburg-Clay | N/A | Recap |
| 2021-04-10 18:31:34April 10, 2021 | Waverly | 8 - 2 | Zane Trace | N/A | Recap |
| 2021-04-10 18:33:02April 10, 2021 | Unioto | 9 - 5 | Logan Elm | N/A | Recap |
| 2021-04-10 18:33:27April 10, 2021 | Unioto | 13 - 7 | Logan Elm | N/A | Recap |
| 2021-04-10 20:21:41April 10, 2021 | Belpre | 15 - 4 | Caldwell | N/A | Recap |
| 2021-04-10 20:37:24April 10, 2021 | Federal Hocking | 2 - 9 | River Valley | N/A | Recap |
| 2021-04-12 01:45:48April 12, 2021 | Ironton | 6 - 5 | Portsmouth | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Federal Hocking | 8 - 5 | Belpre | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Circleville | 3 - 5 | Bloom-Carroll | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Notre Dame | 0 - 10 | Clay | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | South Point | 1 - 13 | Coal Grove | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Meadowbrook | 9 - 5 | Crooksville | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Wellston | 6 - 2 | Nelsonville-York | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | West Muskingum | 3 - 5 | New Lexington | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Sheridan | 2 - 1 | River View | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Gallia Academy | 2 - 5 | Rock Hill | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Western | 5 - 17 | Sciotoville | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Green | 2 - 9 | Symmes Valley | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | South Gallia | 1 - 14 | Trimble | N/A | Recap |
| 2021-04-12 14:00:00April 12, 2021 | Fort Frye | 5 - 4 | Warren | N/A | Recap |
| 2021-04-12 15:15:14April 12, 2021 | Fairfield Union | 14 - 1 | Logan Elm | N/A | Recap |
| 2021-04-12 15:58:28April 12, 2021 | Valley | 2 - 6 | Minford | N/A | Recap |
| 2021-04-12 16:00:42April 12, 2021 | Marietta | 10 - 0 | Waterford | N/A | Recap |
| 2021-04-12 16:05:00April 12, 2021 | Fairland | 13 - 3 | Chesapeake | N/A | Recap |
| 2021-04-12 16:05:46April 12, 2021 | Wheelersburg | 11 - 6 | Waverly | N/A | Recap |
| 2021-04-12 16:07:23April 12, 2021 | Oak Hill | 6 - 0 | South Webster | N/A | Recap |
| 2021-04-12 16:08:24April 12, 2021 | River Valley | 0 - 5 | Athens | N/A | Recap |
| 2021-04-12 16:09:36April 12, 2021 | Unioto | 11 - 1 | Zane Trace | N/A | Recap |
| 2021-04-12 16:11:28April 12, 2021 | Adena | 3 - 0 | Piketon | N/A | Recap |
| 2021-04-12 16:12:13April 12, 2021 | Westfall | 5 - 2 | Southeastern | N/A | Recap |
| 2021-04-12 16:14:00April 12, 2021 | Eastern Meigs | 10 - 0 | Southern | N/A | Recap |
| 2021-04-12 16:15:11April 12, 2021 | Cambridge | 4 - 3 | St. Clairsville | N/A | Recap |
| 2021-04-12 20:29:52April 12, 2021 | Washington | 2 - 6 | Chillicothe | N/A | Recap |
| 2021-04-13 09:08:16April 13, 2021 | Meigs | 1 - 2 | Fisher Catholic | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Valley | 7 - 4 | Clay | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | West Union | 0 - 33 | Eastern Brown | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Ironton | 9 - 2 | Fairview (KY) | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Fairfield | 7 - 1 | Fayetteville-Perry | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Lynchburg-Clay | 3 - 2 | Manchester | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Crooksville | 1 - 2 | Maysville | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Belpre | 13 - 1 | Nelsonville-York | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Huntington | 6 - 0 | Paint Valley | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Northwest | 8 - 7 | Portsmouth | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | St. Joseph | 13 - 3 | Sciotoville | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | John Glenn | 3 - 9 | Sheridan | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | McClain | 14 - 4 | South Point | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Raceland (KY) | 16 - 0 | South Webster | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Oak Hill | 8 - 7 | Westfall | N/A | Recap |
| 2021-04-13 14:00:00April 13, 2021 | Peebles | 6 - 9 | Whiteoak | N/A | Recap |
| 2021-04-13 14:45:40April 13, 2021 | Vinton County | 9 - 6 | Alexander | N/A | Recap |
| 2021-04-13 14:59:26April 13, 2021 | Wellston | 0 - 10 | Gallia Academy | N/A | Recap |
| 2021-04-13 16:02:27April 13, 2021 | North Adams | 14 - 2 | Ripley | N/A | Recap |
| 2021-04-13 17:49:56April 13, 2021 | Portsmouth West | 19 - 2 | Beaver Eastern | N/A | Recap |
| 2021-04-13 21:04:59April 13, 2021 | Jackson | 16 - 5 | Adena | N/A | Recap |
| 2021-04-13 21:09:19April 13, 2021 | Trimble | 9 - 2 | Miller | N/A | Recap |
| 2021-04-13 21:27:54April 13, 2021 | Fisher Catholic | 16 - 0 | Miller | N/A | Recap |
| 2021-04-14 01:47:26April 14, 2021 | Ironton | 12 - 1 | Chesapeake | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Alexander | 7 - 9 | Athens | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Wheelersburg | 13 - 1 | Beaver Eastern | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | McClain | 1 - 5 | Chillicothe | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Liberty Union | 4 - 7 | Circleville | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Fairfield Union | 11 - 1 | Hamilton Township | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Amanda-Clearcreek | 5 - 3 | Logan Elm | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | North Adams | 6 - 3 | Lynchburg-Clay | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Huntington | 10 - 7 | Piketon | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Adena | 10 - 0 | Southeastern | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Oak Hill | 0 - 5 | Valley | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Nelsonville-York | 5 - 15 | Vinton County | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | New Philadelphia | 3 - 4 | Warren | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Trimble | 0 - 13 | Waterford | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Belpre | 3 - 8 | Wellston | N/A | Recap |
| 2021-04-14 14:00:00April 14, 2021 | Symmes Valley | 12 - 2 | Whiteoak | N/A | Recap |
| 2021-04-14 21:06:42April 14, 2021 | Jackson | 13 - 3 | Washington | N/A | Recap |
| 2021-04-14 21:19:49April 14, 2021 | Marietta | 7 - 3 | Cambridge | N/A | Recap |
| 2021-04-14 21:21:16April 14, 2021 | Warren | 4 - 3 | New Philadelphia | N/A | Recap |
| 2021-04-14 21:22:13April 14, 2021 | Unioto | 10 - 6 | Westfall | N/A | Recap |
| 2021-04-14 21:24:17April 14, 2021 | Waverly | 4 - 3 | Northwest | N/A | Recap |
| 2021-04-14 21:26:38April 14, 2021 | Zane Trace | 11 - 2 | Paint Valley | N/A | Recap |
| 2021-04-14 21:35:19April 14, 2021 | Hillsboro | 1 - 2 | Miami Trace | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Northwest | 4 - 3 | Beaver Eastern | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Minford | 4 - 3 | Fairland | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Manchester | 9 - 1 | Fayetteville-Perry | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Alexander | 12 - 2 | Federal Hocking | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | McClain | 7 - 5 | Huntington | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | South Point | 5 - 15 | Notre Dame | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Lynchburg-Clay | 4 - 5 | Paint Valley | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Crooksville | 6 - 5 | Philo | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | St. Joseph | 4 - 2 | River Valley | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | New Lexington | 5 - 4 | Sheridan | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Logan | 0 - 13 | Unioto | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | North Adams | 22 - 12 | West Union | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | Eastern Brown | 2 - 1 | Western Brown | N/A | Recap |
| 2021-04-15 14:00:00April 15, 2021 | South Webster | 3 - 5 | Portsmouth West | N/A | Recap |
| 2021-04-15 20:40:59April 15, 2021 | Washington | 2 - 9 | Southeastern | N/A | Recap |
| 2021-04-16 02:00:22April 16, 2021 | Ironton | 4 - 3 | Rock Hill | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Unioto | 11 - 1 | Adena | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Fairfield Union | 1 - 4 | Bloom-Carroll | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Logan Elm | 3 - 8 | Circleville | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Green | 0 - 11 | Clay | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Fairland | 2 - 1 | Coal Grove | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Warren | 4 - 8 | Dover | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Portsmouth | 0 - 4 | Gallia Academy | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Hillsboro | 10 - 0 | McClain | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Fairfield Christian | 11 - 1 | Miller | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Northwest | 0 - 2 | Minford | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Meigs | 12 - 3 | Nelsonville-York | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Western | 5 - 8 | Notre Dame | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Piketon | 8 - 0 | Paint Valley | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Marietta | 2 - 6 | Eastern Meigs | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Waterford | 19 - 0 | South Gallia | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Chesapeake | 15 - 12 | South Point | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Belpre | 0 - 11 | Southern | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Huntington | 10 - 5 | Southeastern | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Sciotoville | 0 - 20 | St. Joseph | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Federal Hocking | 9 - 2 | Trimble | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Athens | 2 - 1 | Vinton County | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Valley | 1 - 3 | Waverly | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | River Valley | 8 - 1 | Wellston | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Zane Trace | 4 - 9 | Westfall | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | South Webster | 1 - 20 | Wheelersburg | N/A | Recap |
| 2021-04-16 14:00:00April 16, 2021 | Oak Hill | 5 - 4 | Portsmouth West | N/A | Recap |
| 2021-04-16 21:04:48April 16, 2021 | Washington | 5 - 6 | Miami Trace | N/A | Recap |
| 2021-04-16 21:07:41April 16, 2021 | Chillicothe | 3 - 9 | Jackson | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Athens | 1 - 14 | Central Crossing | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Logan Elm | 3 - 6 | Chillicothe | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Georgetown | 1 - 13 | Eastern Brown | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Coal Grove | 0 - 8 | Gallia Academy | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Fisher Catholic | 12 - 2 | Logan | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Meigs | 3 - 2 | New Lexington | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Peebles | 1 - 10 | Paint Valley | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | North Adams | 2 - 0 | Portsmouth | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | South Gallia | 6 - 14 | Sciotoville | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Fairfield Union | 4 - 14 | Sheridan | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Warren | 9 - 8 | Wheeling Park (WV) | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Circleville | 15 - 4 | Zane Trace | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Athens | 3 - 0 | Central Crossing | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Peebles | 2 - 12 | Paint Valley | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Fairfield Union | 5 - 6 | Sheridan | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Warren | 3 - 12 | Wheeling Park (WV) | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | South Gallia | 5 - 0 | Sciotoville | N/A | Recap |
| 2021-04-17 14:00:00April 17, 2021 | Meigs | 0 - 3 | New Lexington | N/A | Recap |
| 2021-04-17 16:14:02April 17, 2021 | North Adams | 10 - 0 | Georgetown | N/A | Recap |
| 2021-04-17 18:32:03April 17, 2021 | Wheelersburg | 13 - 1 | Beaver Eastern | N/A | Recap |
| 2021-04-17 20:13:33April 17, 2021 | Eastern Brown | 9 - 5 | Portsmouth | N/A | Recap |
| 2021-04-17 21:05:56April 17, 2021 | Washington | 1 - 3 | Adena | N/A | Recap |
| 2021-04-17 21:19:04April 17, 2021 | Jackson | 7 - 9 | Lakota East | N/A | Recap |
| 2021-04-17 21:45:55April 17, 2021 | Waverly | 5 - 4 | Cincinnati Country Day | N/A | Recap |
| 2021-04-18 14:00:00April 18, 2021 | Athens | 4 - 5 | Logan | N/A | Recap |
| 2021-04-19 00:44:24April 19, 2021 | East Clinton | 5 - 16 | Lynchburg-Clay | N/A | Recap |
| 2021-04-19 02:01:54April 19, 2021 | Ironton | 16 - 0 | South Point | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Westfall | 6 - 5 | Adena | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Nelsonville-York | 9 - 13 | Alexander | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Circleville | 3 - 6 | Amanda-Clearcreek | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Minford | 14 - 3 | Beaver Eastern | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Portsmouth | 6 - 1 | Coal Grove | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Coshocton | 6 - 5 | Crooksville | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Teays Valley | 5 - 1 | Fairfield Union | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Gallia Academy | 5 - 3 | Fairland | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | South Gallia | 1 - 16 | Federal Hocking | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Unioto | 7 - 8 | Huntington | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Liberty Union | 5 - 3 | Logan Elm | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Fairfield | 6 - 4 | Manchester | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Dover | 5 - 0 | Marietta | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | New Lexington | 4 - 5 | Meadowbrook | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Wellston | 0 - 1 | Meigs | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Grove City Christian | 13 - 2 | Miller | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Oak Hill | 7 - 6 | Northwest | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Clay | 16 - 2 | Notre Dame | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Zane Trace | 9 - 0 | Piketon | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Vinton County | 5 - 7 | River Valley | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Green | 1 - 14 | St. Joseph | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Sheridan | 4 - 0 | Tri-Valley | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | South Webster | 0 - 1 | Valley | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Parkersburg South (WV)  | 2 - 5 | Warren | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Southern | 1 - 9 | Waterford | N/A | Recap |
| 2021-04-19 14:00:00April 19, 2021 | Waverly | 5 - 2 | Portsmouth West | N/A | Recap |
| 2021-04-19 16:14:02April 19, 2021 | Chesapeake | 3 - 4 | Rock Hill | N/A | Recap |
| 2021-04-19 18:21:30April 19, 2021 | West Union | 0 - 13 | Ripley | N/A | Recap |
| 2021-04-19 18:53:02April 19, 2021 | Eastern Meigs | 0 - 1 | Belpre | N/A | Recap |
| 2021-04-19 21:08:54April 19, 2021 | Jackson | 2 - 7 | Miami Trace | N/A | Recap |
| 2021-04-19 21:11:57April 19, 2021 | Washington | 10 - 0 | McClain | N/A | Recap |
| 2021-04-19 21:37:38April 19, 2021 | Hillsboro | 10 - 7 | Chillicothe | N/A | Recap |
| 2021-04-20 02:03:16April 20, 2021 | Ironton | 12 - 7 | Clay | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Trimble | 2 - 9 | Alexander | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Symmes Valley | 11 - 1 | Chesapeake | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Eastern Brown | 10 - 0 | Fairfield | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Whiteoak | 5 - 1 | Fayetteville-Perry | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Eastern Meigs | 7 - 4 | Federal Hocking | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Northwest | 1 - 11 | Huntington | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Teays Valley | 18 - 5 | Logan | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Peebles | 2 - 1 | Lynchburg-Clay | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Belpre | 5 - 6 | Marietta | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Manchester | 2 - 7 | North Adams | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Warren | 3 - 6 | Parkersburg South (WV) | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Gallia Academy | 5 - 0 | Point Pleasant (WV) | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | West Union | 8 - 13 | Ripley | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Wellston | 17 - 0 | South Gallia | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Circleville | 9 - 2 | Southeastern | N/A | Recap |
| 2021-04-20 14:00:00April 20, 2021 | Fort Frye | - | Waterford | N/A | Recap |
| 2021-04-20 18:30:07April 20, 2021 | Beaver Eastern | 13 - 3 | Sciotoville | N/A | Recap |
| 2021-04-20 19:53:08April 20, 2021 | Chillicothe | 5 - 9 | Unioto | N/A | Recap |
| 2021-04-20 21:13:15April 20, 2021 | Washington | 6 - 5 | Logan Elm | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Zane Trace | 7 - 10 | Adena | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Meigs | 15 - 4 | Alexander | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Nelsonville-York | 5 - 14 | Athens | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Trimble | 3 - 8 | Belpre | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Miller | 2 - 13 | Bishop Rosecrans | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Liberty Union | 11 - 10 | Fairfield Union | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | South Point | 2 - 18 | Gallia Academy | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Circleville | 8 - 2 | Hamilton Township | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Morgan | 4 - 6 | New Lexington | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Symmes Valley | 5 - 1 | Notre Dame | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Minford | 5 - 2 | Oak Hill | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Waverly | 9 - 1 | South Webster | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Piketon | 8 - 4 | Southeastern | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Logan Elm | 0 - 13 | Teays Valley | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Crooksville | 0 - 4 | West Muskingum | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | St. Joseph | 19 - 5 | Western | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Valley | 0 - 3 | Wheelersburg | N/A | Recap |
| 2021-04-21 14:00:00April 21, 2021 | Southern | 4 - 8 | Whiteoak | N/A | Recap |
| 2021-04-21 20:15:20April 21, 2021 | Portsmouth | 17 - 4 | Chesapeake | N/A | Recap |
| 2021-04-21 20:55:35April 21, 2021 | Coal Grove | 4 - 5 | Rock Hill | N/A | Recap |
| 2021-04-21 21:42:32April 21, 2021 | Fairland | 1 - 4 | Ironton | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Peebles | 1 - 0 | Fairfield | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Wheelersburg | 8 - 10 | Greenup County (KY) | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Ripley | 0 - 11 | Lynchburg-Clay | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Whiteoak | 1 - 0 | Manchester | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | New Lexington | 1 - 12 | Maysville | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Wilmington | 9 - 13 | McClain | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Eastern Brown | 12 - 2 | North Adams | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | River Valley | 3 - 1 | Oak Hill | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Sciotoville | 2 - 9 | Rose Hill Christian (KY) | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Clay | 14 - 0 | Sciotoville | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Crooksville | 0 - 4 | Sheridan | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Paint Valley | 16 - 0 | Southeastern | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Athens | 4 - 5 | Warren | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Caldwell | - | Waterford | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Fayetteville-Perry | 11 - 0 | West Union | N/A | Recap |
| 2021-04-22 14:00:00April 22, 2021 | Huntington | 5 - 8 | Westfall | N/A | Recap |
| 2021-04-22 17:52:49April 22, 2021 | Beaver Eastern | 4 - 21 | Northwest | N/A | Recap |
| 2021-04-22 22:03:04April 22, 2021 | Miami Trace | 4 - 0 | Chillicothe | N/A | Recap |
| 2021-04-23 02:04:59April 23, 2021 | Ironton | 7 - 0 | Coal Grove | N/A | Recap |
| 2021-04-23 14:00:00April 23, 2021 | Huntington | 0 - 8 | Adena | N/A | Recap |
| 2021-04-23 14:00:00April 23, 2021 | Gallia Academy |
